Particle Dispersion on Rapidly Folding Random Heteropolymers
نویسندگان
چکیده
منابع مشابه
Particle dispersion on rapidly folding random heteropolymers.
We investigate the dynamics of a particle moving randomly along a disordered heteropolymer subjected to rapid conformational changes which induce superdiffusive motion in chemical coordinates. We study the antagonistic interplay between the enhanced diffusion and the quenched disorder. The dispersion speed exhibits universal behavior independent of the folding statistics. On the other hand it i...
متن کاملLattice model for rapidly folding protein-like heteropolymers.
Protein folding is a relatively fast process considering the astronomical number of conformations in which a protein could find itself. Within the framework of a lattice model, we show that one can design rapidly folding sequences by assigning the strongest attractive couplings to the contacts present in a target native state. Our protein design can be extended to situations with both attractiv...
متن کاملProtein folding and heteropolymers
We present a statistical mechanics approach to the protein folding problem. We first review some of the basic properties of proteins, and introduce some physical models to describe their ther-modynamics. These models rely on a random heteropolymeric description of these non random biomolecules. Various kinds of randomness are investigated, and the connection with disordered systems is discussed...
متن کاملFolding Kinetics of Protein Like Heteropolymers
Using a simple three-dimensional lattice copolymer model and Monte Carlo dynamics, we study the collapse and folding of protein-like heteropolymers. The polymers are 27 monomers long and consist of two monomer types. Although these chains are too long for exhaustive enumeration of all conformations, it is possible to enumerate all the maximally compact conformations, which are 3×3×3 cubes. This...
متن کاملMechanical response of random heteropolymers
We present an analytical theory for heteropolymer deformation, as exemplified experimentally by stretching of single protein molecules. Using replica mean-field theory, we determine phase diagrams for stress-induced unfolding of typical random sequences. This transition is sharp in the limit of infinitely long chain molecules. However, for chain lengths relevant to biological macromolecules, pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2003
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.91.048303